Activity of the Vascular-Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid against Human Head and Neck Carcinoma Xenografts

Activity of the Vascular-Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid against Human Head and Neck Carcinoma Xenografts

Head and neck squamous cell carcinomas (HNSCC) constitute a majority of the tumors of the upper aerodigestive tract and continue to present a significant therapeutic challenge. To explore the potential of vascular-targeted therapy in HNSCC, we investigated the antivascular, antitumor activity of th...

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Bibliographic Details
Main Authors: Mukund Seshadri, Richard Mazurchuk, Joseph A. Spernyak, Arup Bhattacharya, Youcef M. Rustum, David A. Bellnier
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Head and neck cancers
DMXAA
tumor vasculature
MRI
antivascular therapies
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800084

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http://www.sciencedirect.com/science/article/pii/S1476558606800084

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