Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries

<p>Abstract</p> <p>Background</p> <p>Capsular serotypes K1 and K2 of <it>Klebsiella pneumoniae </it>are thought to the major virulence determinants responsible for liver abscess. The intestine is one of the major reservoirs of <it>K. pneumoniae</it&...

Full description

Bibliographic Details
Main Authors: Lin Yi-Tsung, Siu L Kristopher, Lin Jung-Chung, Chen Te-Li, Tseng Chih-Peng, Yeh Kuo-Ming, Chang Feng-Yee, Fung Chang-Phone
Format: Article
Language:English
Published: BMC 2012-01-01
Series:BMC Microbiology
Online Access:http://www.biomedcentral.com/1471-2180/12/13
id doaj-267f53597a6b456ebc49f3585d7d507c
record_format Article
spelling doaj-267f53597a6b456ebc49f3585d7d507c2020-11-24T22:13:24ZengBMCBMC Microbiology1471-21802012-01-011211310.1186/1471-2180-12-13Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countriesLin Yi-TsungSiu L KristopherLin Jung-ChungChen Te-LiTseng Chih-PengYeh Kuo-MingChang Feng-YeeFung Chang-Phone<p>Abstract</p> <p>Background</p> <p>Capsular serotypes K1 and K2 of <it>Klebsiella pneumoniae </it>are thought to the major virulence determinants responsible for liver abscess. The intestine is one of the major reservoirs of <it>K. pneumoniae</it>, and epidemiological studies have suggested that the majority of <it>K. pneumoniae </it>infections are preceded by colonization of the gastrointestinal tract. The possibility of fecal-oral transmission in liver abscess has been raised on the basis of molecular typing of isolates. Data on the serotype distribution of <it>K. pneumoniae </it>in stool samples from healthy individuals has not been previously reported. This study investigated the seroepidemiology of <it>K. pneumoniae </it>isolates from the intestinal tract of healthy Chinese in Asian countries. Stool specimens from healthy adult Chinese residents of Taiwan, Japan, Hong Kong, China, Thailand, Malaysia, Singapore, and Vietnam were collected from August 2004 to August 2010 for analysis.</p> <p>Results</p> <p>Serotypes K1/K2 accounted for 9.8% of all <it>K. pneumoniae </it>isolates from stools in all countries. There was no significant difference in the prevalence of K1/K2 isolates among the countries excluding Thailand and Vietnam. The antimicrobial susceptibility pattern was nearly the same in <it>K. pneumoniae </it>isolates. The result of pulsed-field gel electrophoresis revealed no major clonal cluster of serotype K1 isolates.</p> <p>Conclusions</p> <p>The result showed that Chinese ethnicity itself might be a major factor predisposing to intestinal colonization by serotype K1/K2 <it>K. pneumoniae </it>isolates. The prevalent serotype K1/K2 isolates may partially correspond to the prevalence of <it>K. pneumoniae </it>liver abscess in Asian countries.</p> http://www.biomedcentral.com/1471-2180/12/13
collection DOAJ
language English
format Article
sources DOAJ
author Lin Yi-Tsung
Siu L Kristopher
Lin Jung-Chung
Chen Te-Li
Tseng Chih-Peng
Yeh Kuo-Ming
Chang Feng-Yee
Fung Chang-Phone
spellingShingle Lin Yi-Tsung
Siu L Kristopher
Lin Jung-Chung
Chen Te-Li
Tseng Chih-Peng
Yeh Kuo-Ming
Chang Feng-Yee
Fung Chang-Phone
Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries
BMC Microbiology
author_facet Lin Yi-Tsung
Siu L Kristopher
Lin Jung-Chung
Chen Te-Li
Tseng Chih-Peng
Yeh Kuo-Ming
Chang Feng-Yee
Fung Chang-Phone
author_sort Lin Yi-Tsung
title Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries
title_short Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries
title_full Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries
title_fullStr Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries
title_full_unstemmed Seroepidemiology of <it>Klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in Asian countries
title_sort seroepidemiology of <it>klebsiella pneumoniae </it>colonizing the intestinal tract of healthy chinese and overseas chinese adults in asian countries
publisher BMC
series BMC Microbiology
issn 1471-2180
publishDate 2012-01-01
description <p>Abstract</p> <p>Background</p> <p>Capsular serotypes K1 and K2 of <it>Klebsiella pneumoniae </it>are thought to the major virulence determinants responsible for liver abscess. The intestine is one of the major reservoirs of <it>K. pneumoniae</it>, and epidemiological studies have suggested that the majority of <it>K. pneumoniae </it>infections are preceded by colonization of the gastrointestinal tract. The possibility of fecal-oral transmission in liver abscess has been raised on the basis of molecular typing of isolates. Data on the serotype distribution of <it>K. pneumoniae </it>in stool samples from healthy individuals has not been previously reported. This study investigated the seroepidemiology of <it>K. pneumoniae </it>isolates from the intestinal tract of healthy Chinese in Asian countries. Stool specimens from healthy adult Chinese residents of Taiwan, Japan, Hong Kong, China, Thailand, Malaysia, Singapore, and Vietnam were collected from August 2004 to August 2010 for analysis.</p> <p>Results</p> <p>Serotypes K1/K2 accounted for 9.8% of all <it>K. pneumoniae </it>isolates from stools in all countries. There was no significant difference in the prevalence of K1/K2 isolates among the countries excluding Thailand and Vietnam. The antimicrobial susceptibility pattern was nearly the same in <it>K. pneumoniae </it>isolates. The result of pulsed-field gel electrophoresis revealed no major clonal cluster of serotype K1 isolates.</p> <p>Conclusions</p> <p>The result showed that Chinese ethnicity itself might be a major factor predisposing to intestinal colonization by serotype K1/K2 <it>K. pneumoniae </it>isolates. The prevalent serotype K1/K2 isolates may partially correspond to the prevalence of <it>K. pneumoniae </it>liver abscess in Asian countries.</p>
url http://www.biomedcentral.com/1471-2180/12/13
work_keys_str_mv AT linyitsung seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT siulkristopher seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT linjungchung seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT chenteli seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT tsengchihpeng seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT yehkuoming seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT changfengyee seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
AT fungchangphone seroepidemiologyofitklebsiellapneumoniaeitcolonizingtheintestinaltractofhealthychineseandoverseaschineseadultsinasiancountries
_version_ 1725801256213020672