Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole

Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole

New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared wi...

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Main Authors: Shiv K. Gupta, P. K. Sharma, M. Bansal, B. Kumar
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2011/940586
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spelling doaj-267eb8b461e0429e973929506426dea62020-11-24T21:39:16ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102011-01-018259459710.1155/2011/940586Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazoleShiv K. Gupta0P. K. Sharma1M. Bansal2B. Kumar3Department of Pharmaceutical Science, Shree Ganpati Institute of Technology, NH-24, opp. Jindal Pipes Ltd, Ghaziabad, IndiaMeerut Institute of Engineering and Technology, Partapur Road, Bagpat Croosing, Meerut, IndiaMeerut Institute of Engineering and Technology, Partapur Road, Bagpat Croosing, Meerut, IndiaDepartment of Pharmaceutical Science, Shree Ganpati Institute of Technology, NH-24, opp. Jindal Pipes Ltd, Ghaziabad, IndiaNew series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.http://dx.doi.org/10.1155/2011/940586
collection DOAJ
language English
format Article
sources DOAJ
author Shiv K. Gupta
P. K. Sharma
M. Bansal
B. Kumar
spellingShingle Shiv K. Gupta
P. K. Sharma
M. Bansal
B. Kumar
Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
E-Journal of Chemistry
author_facet Shiv K. Gupta
P. K. Sharma
M. Bansal
B. Kumar
author_sort Shiv K. Gupta
title Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
title_short Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
title_full Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
title_fullStr Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
title_full_unstemmed Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
title_sort synthesis and antifungal activities of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2011-01-01
description New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.
url http://dx.doi.org/10.1155/2011/940586
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AT mbansal synthesisandantifungalactivitiesof5ohydroxyphenyl24aryl3chloro2azetidinon1yl134thiadiazole
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