Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids

Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids

Abstract Background H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the DNA condensation and histone-to-prota...

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Bibliographic Details
Main Authors: Vasantha Shalini, Utsa Bhaduri, Anjhana C. Ravikkumar, Anusha Rengarajan, Rao M. R. Satyanarayana
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Epigenetics & Chromatin
Subjects:
Spermiogenesis
Linker histone
Spermatid
ChIP-sequencing
Histone PTMs
Online Access:https://doi.org/10.1186/s13072-020-00376-2

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