Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 recepto...

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Bibliographic Details
Main Authors:	Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola
Format:	Article
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2007-06-01
Series:	Memórias do Instituto Oswaldo Cruz.
Subjects:	amodiaquine chlorpheniramine resistance reversal malaria children
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300023

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