Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors.
Histone deacetylase (HDAC) inhibitors are being intensively pursued as potential new drugs for a range of diseases, including malaria. HDAC inhibitors are also important tools for the study of epigenetic mechanisms, transcriptional control, and other important cellular processes. In this study the e...
Main Authors: | Katherine T Andrews, Archna P Gupta, Thanh N Tran, David P Fairlie, Geoffrey N Gobert, Zbynek Bozdech |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384084/?tool=EBI |
Similar Items
-
Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle.
by: Balbir K Chaal, et al.
Published: (2010-01-01) -
Inhibition of the histone deacetylase family as a drug target in the human malaria parasite, plasmodium falciparum
by: Ismail, Nabila
Published: (2014) -
Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice
by: Ming Jang Chua, et al.
Published: (2021-12-01) -
Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum.
by: Archna P Gupta, et al.
Published: (2013-02-01) -
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria
by: Vijay Potluri, et al.
Published: (2020-10-01)