Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice.

Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice.

Metformin is used as an anti-diabetic drug. Metformin ameliorates insulin resistance by improving insulin sensitivity in liver and skeletal muscle. Reduced mitochondrial content has been reported in type 2 diabetic muscles and it may contribute to decreased insulin sensitivity characteristic for dia...

Full description

Bibliographic Details
Main Authors:	Jonas M Kristensen, Steen Larsen, Jørn W Helge, Flemming Dela, Jørgen F P Wojtaszewski
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23341947/pdf/?tool=EBI

Similar Items

Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle
by: Nicolas O. Jørgensen, et al.
Published: (2018-04-01)

Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study
by: Steen Larsen, et al.
Published: (2018-01-01)

Metformin, AMPK and Breast Cancer
by: Hadad, Sirwan Mohammed
Published: (2010)

Peak Fat Oxidation Rate Is Closely Associated With Plasma Free Fatty Acid Concentrations in Women; Similar to Men
by: Jacob Frandsen, et al.
Published: (2021-08-01)

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise
by: Janne R. Hingst, et al.
Published: (2020-10-01)

Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial
by: Jonas M. Kristensen, et al.
Published: (2019-12-01)

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
by: Yu Wang, et al.
Published: (2019-11-01)

AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle.
by: Thomas E Jensen, et al.
Published: (2008-01-01)

AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles
by: Jørgen Jensen, et al.
Published: (2017-04-01)

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
by: Loranne Agius, et al.
Published: (2020-05-01)

The effect of metformin-induced AMPK activation on adipogenesis and HIV replication
by: Alexandre, Kabamba Bankoledi
Published: (2008)

AMPK and insulin action--responses to ageing and high fat diet.
by: Christian Frøsig, et al.
Published: (2013-01-01)

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
by: Demin Cheng, et al.
Published: (2021-08-01)

ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2
by: Andreas Mæchel Fritzen, et al.
Published: (2020-05-01)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
by: Luengo, Alba, et al.
Published: (2014)

Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering
by: Nicolas O. Jørgensen, et al.
Published: (2021-09-01)

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
by: Yong Chen, et al.
Published: (2020-06-01)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons.
by: Jacqueline A Bayliss, et al.
Published: (2016-01-01)

Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling
by: Gao, X., et al.
Published: (2018)

Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism
by: Thomas S. Postler, et al.
Published: (2021-09-01)

CARM1 Regulates AMPK Signaling in Skeletal Muscle
by: Derek W. Stouth, et al.
Published: (2020-11-01)

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle
by: Stéphanie Paradis, et al.
Published: (2019-06-01)

Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle
by: Rikuhide Koma, et al.
Published: (2021-03-01)

Erythropoietin treatment enhances mitochondrial function in human skeletal muscle
by: Ulla ePlenge, et al.
Published: (2012-03-01)

Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation
by: Hong-Yue Lai, et al.
Published: (2021-01-01)

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila.
by: Cathy Slack, et al.
Published: (2012-01-01)

Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts.
by: Gilles M Leclerc, et al.
Published: (2013-01-01)

Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation
by: Shumin Yang, et al.
Published: (2013-01-01)

Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated  Protein Kinase (AMPK) Activation
by: Zhaoyu CHEN, et al.
Published: (2013-08-01)

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation
by: Kah Heng Yap, et al.
Published: (2020-09-01)

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1 alpha/PPAR-gamma Activation
by: Bhattamisra, SK, et al.
Published: (2020)

Catalpol ameliorates insulin sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and ampk/sirt1/pgc-1α/ppar-γ activation
by: Bhattamisra, S.K, et al.
Published: (2020)

Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS
by: Tatsuya Deguchi, et al.
Published: (2021-09-01)

The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
by: David M. Thomson
Published: (2018-10-01)

AMPK signaling in skeletal muscle under chronic catabolic stress
by: Chung-Yu Chen, et al.
Published: (2010)

Effect of metformin on skeletal muscle in cardiotoxin-induced degeneration.
by: Tatyana Sergeevna Borodich
Published: (2015-01-01)

Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle
by: Satoshi Maekawa, et al.
Published: (2020-03-01)

PPARα Protein Expression Was Increased by Four Weeks of Intermittent Hypoxic Training via AMPKα2-Dependent Manner in Mouse Skeletal Muscle.
by: Ge Li, et al.
Published: (2015-01-01)

Medical image of the week: Cheyne-Stokes respiration on overnight polysomnography
by: Nahapetian R, et al.
Published: (2014-06-01)

Metformin inhibits cervical cancer cell proliferation via decreased AMPK O-GlcNAcylation
by: Min Young Kim, et al.
Published: (2019-07-01)