Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study
Introduction: Chronic obstructive pulmonary disease (COPD) is a disease characterized by an airflow limitation that is not fully reversible. β 2 -agonists and anticholinergics represent the most effective therapeutic options. Optoelectronic plethysmography (OEP) is a novel technology, which provides...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2012-04-01
|
Series: | Therapeutic Advances in Respiratory Disease |
Online Access: | https://doi.org/10.1177/1753465811433579 |
id |
doaj-265accaa4ea0426a8635e6e0f57a4065 |
---|---|
record_format |
Article |
spelling |
doaj-265accaa4ea0426a8635e6e0f57a40652020-11-25T03:15:28ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46581753-46662012-04-01610.1177/1753465811433579Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot studyRoberto Walter Dal NegroClaudio TuratiClaudio MichelettoFrancesco MenegoniIntroduction: Chronic obstructive pulmonary disease (COPD) is a disease characterized by an airflow limitation that is not fully reversible. β 2 -agonists and anticholinergics represent the most effective therapeutic options. Optoelectronic plethysmography (OEP) is a novel technology, which provides noninvasive steady-state measurements of chest wall kinematics, together with the assessment of the relative contribution of all different thoracic and abdominal compartments to tidal volume. Objectives: The aim of this pilot study was to investigate the changes in quiet breathing due to different long-acting bronchodilators (namely, formoterol and tiotropium) administered to COPD patients of different severity. Methods: Eight moderate-to-severe COPD patients were studied according to a randomized crossover design. All subjects received both the long-acting bronchodilators: formoterol (long-acting β 2 -agonist, 24 µg) and tiotropium (long-acting anticholinergic bronchodilator, 18 µg). The effect of bronchodilators on quiet breathing was evaluated by means of OEP at base conditions, and 2 and 7 hours after inhalation. Results: Both bronchodilators caused changes in the quiet breathing pattern in COPD patients that had previously reported only negligible changes in FEV 1 (ΔFEV 1 = 2.6% after salbutamol). The main changes were observed in increased ventilation per minute, inspiratory and expiratory flow, and decreased breath-by-breath variability. Formoterol induced its main effects during the first 2 hours after inhalation, while tiotropium caused improvements between 2 and 7 hours. Conclusion: Even though a greater cohort of COPD patients is needed in order to confirm the present results, this pilot study reports a novel piece of evidence concerning the effects of bronchodilators on quiet breathing pattern in severe and very severe COPD patients.https://doi.org/10.1177/1753465811433579 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberto Walter Dal Negro Claudio Turati Claudio Micheletto Francesco Menegoni |
spellingShingle |
Roberto Walter Dal Negro Claudio Turati Claudio Micheletto Francesco Menegoni Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study Therapeutic Advances in Respiratory Disease |
author_facet |
Roberto Walter Dal Negro Claudio Turati Claudio Micheletto Francesco Menegoni |
author_sort |
Roberto Walter Dal Negro |
title |
Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study |
title_short |
Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study |
title_full |
Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study |
title_fullStr |
Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study |
title_full_unstemmed |
Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study |
title_sort |
effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in copd patients: a pilot study |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Respiratory Disease |
issn |
1753-4658 1753-4666 |
publishDate |
2012-04-01 |
description |
Introduction: Chronic obstructive pulmonary disease (COPD) is a disease characterized by an airflow limitation that is not fully reversible. β 2 -agonists and anticholinergics represent the most effective therapeutic options. Optoelectronic plethysmography (OEP) is a novel technology, which provides noninvasive steady-state measurements of chest wall kinematics, together with the assessment of the relative contribution of all different thoracic and abdominal compartments to tidal volume. Objectives: The aim of this pilot study was to investigate the changes in quiet breathing due to different long-acting bronchodilators (namely, formoterol and tiotropium) administered to COPD patients of different severity. Methods: Eight moderate-to-severe COPD patients were studied according to a randomized crossover design. All subjects received both the long-acting bronchodilators: formoterol (long-acting β 2 -agonist, 24 µg) and tiotropium (long-acting anticholinergic bronchodilator, 18 µg). The effect of bronchodilators on quiet breathing was evaluated by means of OEP at base conditions, and 2 and 7 hours after inhalation. Results: Both bronchodilators caused changes in the quiet breathing pattern in COPD patients that had previously reported only negligible changes in FEV 1 (ΔFEV 1 = 2.6% after salbutamol). The main changes were observed in increased ventilation per minute, inspiratory and expiratory flow, and decreased breath-by-breath variability. Formoterol induced its main effects during the first 2 hours after inhalation, while tiotropium caused improvements between 2 and 7 hours. Conclusion: Even though a greater cohort of COPD patients is needed in order to confirm the present results, this pilot study reports a novel piece of evidence concerning the effects of bronchodilators on quiet breathing pattern in severe and very severe COPD patients. |
url |
https://doi.org/10.1177/1753465811433579 |
work_keys_str_mv |
AT robertowalterdalnegro effectsoftiotropiumandformoterolonquietbreathingpatternassessedbyoptoelectronicplethysmographyincopdpatientsapilotstudy AT claudioturati effectsoftiotropiumandformoterolonquietbreathingpatternassessedbyoptoelectronicplethysmographyincopdpatientsapilotstudy AT claudiomicheletto effectsoftiotropiumandformoterolonquietbreathingpatternassessedbyoptoelectronicplethysmographyincopdpatientsapilotstudy AT francescomenegoni effectsoftiotropiumandformoterolonquietbreathingpatternassessedbyoptoelectronicplethysmographyincopdpatientsapilotstudy |
_version_ |
1724639126037200896 |