Heterologous Expression of Ilicicolin H Biosynthetic Gene Cluster and Production of a New Potent Antifungal Reagent, Ilicicolin J

Heterologous Expression of Ilicicolin H Biosynthetic Gene Cluster and Production of a New Potent Antifungal Reagent, Ilicicolin J

Ilicicolin H is a broad-spectrum antifungal agent targeting mitochondrial cytochrome bc1 reductase. Unfortunately, ilicicolin H shows reduced activities in vivo. Here, we report our effort on the identification of ilicicolin H biosynthetic gene cluster (BGC) by genomic sequencing a producing strain,...

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Bibliographic Details
Main Authors: Xiaojing Lin, Siwen Yuan, Senhua Chen, Bin Chen, Hui Xu, Lan Liu, Huixian Li, Zhizeng Gao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
ilicicolin H
<i>Neonectria</i> sp. DH2
heterologous production
biosynthetic gene cluster
Online Access:https://www.mdpi.com/1420-3049/24/12/2267

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