Treatment With Lipopolysaccharide Induces Distinct Changes in Metabolite Profile and Body Weight in 129Sv and Bl6 Mouse Strains

Treatment With Lipopolysaccharide Induces Distinct Changes in Metabolite Profile and Body Weight in 129Sv and Bl6 Mouse Strains

Mouse strains differ significantly in their behaviors and responses to pathogenic and pharmacological agents. This study seeks to characterize behavioral and metabolomic profiles of two widely used mouse lines, 129S6/SvEvTac (129Sv) and C57BL/6NTac (Bl6), to acute administration of lipopolysaccharid...

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Bibliographic Details
Main Authors: Maria Piirsalu, Egon Taalberg, Kersti Lilleväli, Li Tian, Mihkel Zilmer, Eero Vasar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
lipopolysaccharide
129Sv strain
Bl6 strain
metabolic profiling
inflammation
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00371/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00371/full

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