Subcellular clearance and accumulation of Huntington disease protein: A mini-review

Subcellular clearance and accumulation of Huntington disease protein: A mini-review

Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease caused by an expanded polyglutamine (polyQ) tract in the N-terminal region of mutant huntingtin (mHtt). As a result, mHtt forms aggregates that are abundant in the nuclei and processes of neuronal cells. Althou...

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Bibliographic Details
Main Authors: Ting eZhao, Yan eHong, Xiao-Jiang eLi, Shihua eLi
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Autophagy
Aggregation
Huntingtin
neurodegeneration
Proteasome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00027/full

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