Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage

• Main Authors: Claudia von Montfort, Lirija Alili, Sarah Teuber-Hanselmann, Peter Brenneisen
• Format: Article
• Language: English
• Published: Elsevier 2015-04-01
• Series: Redox Biology
• Subjects: Cerium oxide; Skin cancer; Fibroblasts; Redox-active nanoparticles; Tumor–stroma interaction
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213231714001190

Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already been observed. However, the effect on important parameters such as cell death, proliferation and redox state of the cells needs further clarification. Here, we present that nanoceria prevent HDF from reactive oxygen species (ROS)-induced cell death and stimulate proliferation due to the antioxidative property of these particles.