Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases [version 1; referees: 4 approved]

• Main Authors: Christian Bär, Maria A. Blasco
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2016-01-01
• Series: F1000Research
• Subjects: Aging; Anemias & Hypocellular Marrow Disorders; Cellular Death & Stress Responses; Control of Gene Expression; Developmental Molecular Mechanisms; Diabetes & Obesity; Drug Discovery & Design; Endocrinology; Immunopharmacology & Hematologic Pharmacology; Medical Genetics; Mood Disorders; Neurobiology of Disease & Regeneration; Nuclear Structure & Function; Social & Behavioral Determinants of Health
• Online Access: http://f1000research.com/articles/5-89/v1

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging. Here, we discuss the role of telomere shortening as a direct cause for aging and age-related diseases. In particular, we draw attention to the fact that telomere length influences longevity. Furthermore, we discuss intrinsic and environmental factors that can impact on human telomere erosion. Finally, we highlight recent advances in telomerase-based therapeutic strategies for the treatment of diseases associated with extremely short telomeres owing to mutations in telomerase, as well as age-related diseases, and ultimately aging itself.