Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections
Viral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately 90 drugs approved for the treatment of human viral infections. As r...
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MDPI AG
2020-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/4/942 |
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doaj-263248daf29442b893c38518e8a0de742020-11-25T02:39:14ZengMDPI AGMolecules1420-30492020-02-0125494210.3390/molecules25040942molecules25040942Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral InfectionsGeorgeta Serban0Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga, 410028 Oradea, RomaniaViral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately 90 drugs approved for the treatment of human viral infections. As resistance toward available antiviral drugs has become a global threat to health, there is an intrinsic need to identify new scaffolds that are useful in discovering innovative, less toxic and highly active antiviral agents. 1,3,4-Thiadiazole derivatives have been extensively studied due to their pharmacological profile, physicochemical and pharmacokinetic properties. This review provides an overview of the various synthetic compounds containing the 2-amino-1,3,4-thiadiazole moiety that has been evaluated for antiviral activity against several viral strains and could be considered possible prototypes for the development of new antiviral drugs.https://www.mdpi.com/1420-3049/25/4/9422-amino-1,3,4-thiadiazoleviral infectionsantiviral agentsdrug resistanceinhibitory concentrationmechanism of action |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Georgeta Serban |
| spellingShingle |
Georgeta Serban Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections Molecules 2-amino-1,3,4-thiadiazole viral infections antiviral agents drug resistance inhibitory concentration mechanism of action |
| author_facet |
Georgeta Serban |
| author_sort |
Georgeta Serban |
| title |
Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections |
| title_short |
Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections |
| title_full |
Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections |
| title_fullStr |
Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections |
| title_full_unstemmed |
Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections |
| title_sort |
synthetic compounds with 2-amino-1,3,4-thiadiazole moiety against viral infections |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2020-02-01 |
| description |
Viral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately 90 drugs approved for the treatment of human viral infections. As resistance toward available antiviral drugs has become a global threat to health, there is an intrinsic need to identify new scaffolds that are useful in discovering innovative, less toxic and highly active antiviral agents. 1,3,4-Thiadiazole derivatives have been extensively studied due to their pharmacological profile, physicochemical and pharmacokinetic properties. This review provides an overview of the various synthetic compounds containing the 2-amino-1,3,4-thiadiazole moiety that has been evaluated for antiviral activity against several viral strains and could be considered possible prototypes for the development of new antiviral drugs. |
| topic |
2-amino-1,3,4-thiadiazole viral infections antiviral agents drug resistance inhibitory concentration mechanism of action |
| url |
https://www.mdpi.com/1420-3049/25/4/942 |
| work_keys_str_mv |
AT georgetaserban syntheticcompoundswith2amino134thiadiazolemoietyagainstviralinfections |
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