Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression

Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression

Naïve depression patients show alterations in serotonin transporter (SERT) and serotonin 2A (5HT2A) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression. Repeated corticosterone (CORT) induces a consistent...

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Bibliographic Details
Main Authors: Raquel Romay-Tallon, Erin Kulhawy, Kyle J. Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M. Olivares, Lisa E. Kalynchuk, Hector J. Caruncho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
depression
corticosterone
lipid rafts
biomarkers
lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01149/full

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