No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study
Wei-Hua Li,1 Zi-Guan Zhang,1 Zheng-Rong Huang,1 Wei Zhang,1 Zhi-Bin Li,2 Zhong-Quan Qi3 1Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 2Epidemiology Research Unit, The First Affiliated Hospital of...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2018-09-01
|
Series: | Cancer Management and Research |
Subjects: | |
Online Access: | https://www.dovepress.com/no-association-between-tumor-laterality-and-cardiac-related-mortality--peer-reviewed-article-CMAR |
id |
doaj-2627b5fd69b5429bbdb4269482a4331b |
---|---|
record_format |
Article |
spelling |
doaj-2627b5fd69b5429bbdb4269482a4331b2020-11-24T20:44:06ZengDove Medical PressCancer Management and Research1179-13222018-09-01Volume 103649365640691No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based studyLi WHZhang ZGHuang ZRZhang WLi ZBQi ZQWei-Hua Li,1 Zi-Guan Zhang,1 Zheng-Rong Huang,1 Wei Zhang,1 Zhi-Bin Li,2 Zhong-Quan Qi3 1Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 2Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 3Organ Transplantation Institute, Medical College, Xiamen University, Xiamen 361005, People’s Republic of China Introduction: To assess the effect of tumor laterality to cardiac-related deaths of breast cancer in the current radiation practices using a large modern population-based study.Methods: Women diagnosed with breast cancer from 2000 to 2008 were included using the current Surveillance, Epidemiology, and End Results database. The primary outcome of this study was the cardiac-related mortality. Multivariate analysis was performed using the Cox proportional hazards model to analyze the cardiac-related mortality including demographic, clinicopathologic, and treatment factors.Results: We identified 168,761 breast cancer patients, including 85,006 (50.4%) patients with left-sided tumors and 83,755 (49.6%) patients with right-sided tumors. The median follow-up period was 8.8 years. The 10-year cardiac-related mortality was 2.3% and 2.3% in left- and right-sided tumors, respectively (P=0.685). The results indicated that patients with older age, non-Hispanic Black, receipt of mastectomy, and married status were the independent adverse factors for cardiac-related mortality. However, left-sided tumors were not associated to a higher risk of cardiac-related mortality than right-sided tumors following postoperative radiotherapy (right vs left, hazard ratios 1.025, 95% CI 0.856–1.099, P=0.484). The risk of cardiac-related mortality in the entire cohort was increased with the extension of follow-up time. However, there was still not significantly different between left- and right-sided tumors. Subgroup analysis also found no association between tumor laterality and cardiac-related mortality after postoperative radiotherapy based on various demographics and treatment factors.Conclusion: With a median follow-up of 8.8 years, no significant differences were found in cardiac-related mortality between left- and right-sided tumors under current radiation practices of breast cancer patients. Keywords: breast cancer, radiotherapy, tumor laterality, cardiac mortalityhttps://www.dovepress.com/no-association-between-tumor-laterality-and-cardiac-related-mortality--peer-reviewed-article-CMARBreast cancerradiotherapytumor lateralitycardiac mortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li WH Zhang ZG Huang ZR Zhang W Li ZB Qi ZQ |
spellingShingle |
Li WH Zhang ZG Huang ZR Zhang W Li ZB Qi ZQ No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study Cancer Management and Research Breast cancer radiotherapy tumor laterality cardiac mortality |
author_facet |
Li WH Zhang ZG Huang ZR Zhang W Li ZB Qi ZQ |
author_sort |
Li WH |
title |
No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
title_short |
No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
title_full |
No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
title_fullStr |
No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
title_full_unstemmed |
No association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
title_sort |
no association between tumor laterality and cardiac-related mortality in breast cancer patients after radiotherapy: a population-based study |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2018-09-01 |
description |
Wei-Hua Li,1 Zi-Guan Zhang,1 Zheng-Rong Huang,1 Wei Zhang,1 Zhi-Bin Li,2 Zhong-Quan Qi3 1Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 2Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University, Xiamen 361003, People’s Republic of China; 3Organ Transplantation Institute, Medical College, Xiamen University, Xiamen 361005, People’s Republic of China Introduction: To assess the effect of tumor laterality to cardiac-related deaths of breast cancer in the current radiation practices using a large modern population-based study.Methods: Women diagnosed with breast cancer from 2000 to 2008 were included using the current Surveillance, Epidemiology, and End Results database. The primary outcome of this study was the cardiac-related mortality. Multivariate analysis was performed using the Cox proportional hazards model to analyze the cardiac-related mortality including demographic, clinicopathologic, and treatment factors.Results: We identified 168,761 breast cancer patients, including 85,006 (50.4%) patients with left-sided tumors and 83,755 (49.6%) patients with right-sided tumors. The median follow-up period was 8.8 years. The 10-year cardiac-related mortality was 2.3% and 2.3% in left- and right-sided tumors, respectively (P=0.685). The results indicated that patients with older age, non-Hispanic Black, receipt of mastectomy, and married status were the independent adverse factors for cardiac-related mortality. However, left-sided tumors were not associated to a higher risk of cardiac-related mortality than right-sided tumors following postoperative radiotherapy (right vs left, hazard ratios 1.025, 95% CI 0.856–1.099, P=0.484). The risk of cardiac-related mortality in the entire cohort was increased with the extension of follow-up time. However, there was still not significantly different between left- and right-sided tumors. Subgroup analysis also found no association between tumor laterality and cardiac-related mortality after postoperative radiotherapy based on various demographics and treatment factors.Conclusion: With a median follow-up of 8.8 years, no significant differences were found in cardiac-related mortality between left- and right-sided tumors under current radiation practices of breast cancer patients. Keywords: breast cancer, radiotherapy, tumor laterality, cardiac mortality |
topic |
Breast cancer radiotherapy tumor laterality cardiac mortality |
url |
https://www.dovepress.com/no-association-between-tumor-laterality-and-cardiac-related-mortality--peer-reviewed-article-CMAR |
work_keys_str_mv |
AT liwh noassociationbetweentumorlateralityandcardiacrelatedmortalityinbreastcancerpatientsafterradiotherapyapopulationbasedstudy AT zhangzg noassociationbetweentumorlateralityandcardiacrelatedmortalityinbreastcancerpatientsafterradiotherapyapopulationbasedstudy AT huangzr noassociationbetweentumorlateralityandcardiacrelatedmortalityinbreastcancerpatientsafterradiotherapyapopulationbasedstudy AT zhangw noassociationbetweentumorlateralityandcardiacrelatedmortalityinbreastcancerpatientsafterradiotherapyapopulationbasedstudy AT lizb noassociationbetweentumorlateralityandcardiacrelatedmortalityinbreastcancerpatientsafterradiotherapyapopulationbasedstudy AT qizq noassociationbetweentumorlateralityandcardiacrelatedmortalityinbreastcancerpatientsafterradiotherapyapopulationbasedstudy |
_version_ |
1716818338002239488 |