Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia

Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia

Locus Coeruleus (LC) is the main noradrenergic nucleus of the central nervous system, and its neurons widely innervate the whole brain. LC is severely degenerated both in Alzheimer’s disease (AD) and in Parkinson’s disease (PD), years before the onset of clinical symptoms, through mechanisms that di...

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Bibliographic Details
Main Authors: Filippo Sean Giorgi, Francesca Biagioni, Alessandro Galgani, Nicola Pavese, Gloria Lazzeri, Francesco Fornai
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Locus Coeruleus
neuroinflammation
noradrenaline
Alzheimer’s disease
Parkinson’s disease
microglia
Online Access:https://www.mdpi.com/1422-0067/21/22/8630

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