ATP-Dependent Ligases and AEP Primases Affect the Profile and Frequency of Mutations in Mycobacteria under Oxidative Stress

ATP-Dependent Ligases and AEP Primases Affect the Profile and Frequency of Mutations in Mycobacteria under Oxidative Stress

The mycobacterial nonhomologous end-joining pathway (NHEJ) involved in double-strand break (DSB) repair consists of the multifunctional ATP-dependent ligase LigD and the DNA bridging protein Ku. The other ATP-dependent ligases LigC and AEP-primase PrimC are considered as backup in this process. The...

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Bibliographic Details
Main Authors: Anna Brzostek, Filip Gąsior, Jakub Lach, Lidia Żukowska, Ewelina Lechowicz, Małgorzata Korycka-Machała, Dominik Strapagiel, Jarosław Dziadek
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
<i>Mycobacterium</i>
ATP-dependent ligases
AEP primases
NHEJ
BER
Online Access:https://www.mdpi.com/2073-4425/12/4/547

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