<sup>89</sup>Zr-Labeled Domain II-Specific scFv-Fc ImmunoPET Probe for Imaging Epidermal Growth Factor Receptor In Vivo

<sup>89</sup>Zr-Labeled Domain II-Specific scFv-Fc ImmunoPET Probe for Imaging Epidermal Growth Factor Receptor In Vivo

Epidermal growth factor receptor I (EGFR) is overexpressed in many cancers. The extracellular domain of EGFR has four binding epitopes (domains I- IV). All clinically approved anti-EGFR antibodies bind to domain III. Imaging agents that bind to domains other than domain III of EGFR are needed for ac...

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Bibliographic Details
Main Authors: Elahe Alizadeh, Khan Behlol Ayaz Ahmed, Viswas Raja Solomon, Vijay Gaja, Wendy Bernhard, Amal Makhlouf, Carolina Gonzalez, Kris Barreto, Angel Casaco, C. Ronald Geyer, Humphrey Fonge
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
domain II-specific
EGFR
immunoPET imaging
monitoring response
89Zr
anti-EGFR scFv-Fc fragment
Online Access:https://www.mdpi.com/2072-6694/13/3/560

Internet

https://www.mdpi.com/2072-6694/13/3/560

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