Feature-Based Classification of Amino Acid Substitutions outside Conserved Functional Protein Domains

Feature-Based Classification of Amino Acid Substitutions outside Conserved Functional Protein Domains

There are more than 500 amino acid substitutions in each human genome, and bioinformatics tools irreplaceably contribute to determination of their functional effects. We have developed feature-based algorithm for the detection of mutations outside conserved functional domains (CFDs) and compared its...

Full description

Bibliographic Details
Main Authors:	Branislava Gemovic, Vladimir Perovic, Sanja Glisic, Nevena Veljkovic
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2013/948617

Similar Items

Alignment-free method for functional annotation of amino acid substitutions: Application on epigenetic factors involved in hematologic malignancies.
by: Branislava Gemović, et al.
Published: (2021-01-01)

Natural autoantibodies in healthy neonatals recognizing a peptide derived from the second conserved region of HIV-1 GP120
by: Đorđević-Vujičić Ana, et al.
Published: (2014-01-01)

Role of genetic markers in sport and recreational physical activity
by: Glišić Sanja, et al.
Published: (2016-01-01)

Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China.
by: Veljko Veljkovic, et al.
Published: (2016-01-01)

The first insight into the genetic structure of the population of modern Serbia
by: Tamara Drljaca, et al.
Published: (2021-07-01)

Deletion or substitution of conserved amino acid residues at the tip of the domain IV of Tet(O) impairs tetracycline resistance
by: Mukherjee, Oindrila
Published: (2011)

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease [v1; ref status: indexed, http://f1000r.es/5bs]
by: Veljko Veljkovic, et al.
Published: (2015-05-01)

Variation in structural location and amino acid conservation of functional sites in protein domain families
by: Copley Richard R, et al.
Published: (2005-08-01)

A simple method for calculation of basic molecular properties of nutrients and their use as a criterion for a healthy diet [version 1; referees: 2 approved]
by: Veljko Veljkovic, et al.
Published: (2017-01-01)

FLU, an amino acid substitution model for influenza proteins
by: Gascuel Olivier, et al.
Published: (2010-04-01)

Single Amino Acid Substitution in the Vicinity of a Receptor-Binding Domain Changes Protein–Peptide Binding Affinity
by: Galina Malovichko, et al.
Published: (2017-09-01)

Novel phylogenetic algorithm to monitor human tropism in Egyptian H5N1-HPAIV reveals evolution toward efficient human-to-human transmission.
by: Vladimir R Perovic, et al.
Published: (2013-01-01)

Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection [v1; ref status: indexed, http://f1000r.es/51s]
by: Veljko Veljkovic, et al.
Published: (2015-02-01)

Virtual screen for repurposing approved and experimental drugs for candidate inhibitors of EBOLA virus infection [v2; ref status: indexed, http://f1000r.es/53d]
by: Veljko Veljkovic, et al.
Published: (2015-02-01)

Studies on #beta#-substituted amino acids
by: Mellor, Lisa Catherine
Published: (1993)

Pattern of amino acid substitutions in transmembrane domains of β-barrel membrane proteins for detecting remote homologs in bacteria and mitochondria.
by: David Jimenez-Morales, et al.
Published: (2011-01-01)

Graph-based feature extraction: A new proposal to study the classification of music signals outside the time-frequency domain.
by: Dirceu de Freitas Piedade Melo, et al.
Published: (2020-01-01)

Evolution of 2014/15 H3N2 influenza viruses circulating in US: consequences for vaccine effectiveness and possible new pandemic
by: Veljko eVeljkovic, et al.
Published: (2015-12-01)

Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors
by: Draginja Radosevic, et al.
Published: (2019-03-01)

Protein sequences classification by means of feature extraction with substitution matrices
by: Saidi Rabie, et al.
Published: (2010-04-01)

Isolation of Fission Yeast Condensin Temperature-Sensitive Mutants with Single Amino Acid Substitutions Targeted to Hinge Domain
by: Xingya Xu, et al.
Published: (2019-05-01)

Predicting the functional effect of amino acid substitutions and indels.
by: Yongwook Choi, et al.
Published: (2012-01-01)

The Syntheses of Amino Substituted Salicylic Acids and Related Compounds
by: Gerber, Martin
Published: (1949)

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.
by: Kelly Williamson, et al.
Published: (2013-01-01)

Functional analysis of conserved aromatic amino acids in the discoidin domain of <it>Paenibacillus </it>β-1,3-glucanase
by: Cheng Yueh-Mei, et al.
Published: (2009-01-01)

Domain Diversity and Polarization Switching in Amino Acid β-Glycine
by: Daria Vasileva, et al.
Published: (2019-04-01)

Neighbor Preferences of Amino Acids and Context-Dependent Effects of Amino Acid Substitutions in Human, Mouse, and Dog
by: Mingchuan Fu, et al.
Published: (2014-09-01)

Amino acid repeats avert mRNA folding through conservative substitutions and synonymous codons, regardless of codon bias
by: Sailen Barik
Published: (2017-12-01)

Identification of Conserved Amino Acid Substitutions During Serial Infection of Pregnant Cattle and Sheep With Bovine Viral Diarrhea Virus
by: Thibaud Kuca, et al.
Published: (2018-06-01)

The use of orthologous sequences to predict the impact of amino acid substitutions on protein function.
by: Nicholas J Marini, et al.
Published: (2010-05-01)

Markov models of amino acid substitution to study proteins with intrinsically disordered regions.
by: Adam M Szalkowski, et al.
Published: (2011-01-01)

Amino-Acid Substitutions In Membrane Proteins: Applications To Homology Recognition And Comparative Modelling
by: Mizuguchi Kenji, et al.
Published: (2005-09-01)

Identifying Pathogenic Amino Acid Substitutions in Human Proteins Using Deep Learning
by: Kvist, Alexander
Published: (2018)

Protein evolution in deep sea bacteria: an analysis of amino acids substitution rates
by: Valle Giorgio, et al.
Published: (2008-11-01)

The ranging of amino acids substitution matrices of various types in accordance with the alignment accuracy criterion
by: Valery Polyanovsky, et al.
Published: (2020-09-01)

Protective antigenic sites in respiratory syncytial virus G attachment protein outside the central conserved and cysteine noose domains.
by: Jeehyun Lee, et al.
Published: (2018-08-01)

Amino acid properties conserved in molecular evolution.
by: Witold R Rudnicki, et al.
Published: (2014-01-01)

Radical Functionalization of Unsaturated Amino Acids: Synthesis of Side-Chain-Fluorinated, Azido-Substituted, and Hydroxylated Amino Acids
by: Philip A. P. Reeve, et al.
Published: (2019-06-01)

Amino acid "little Big Bang": Representing amino acid substitution matrices as dot products of Euclidian vectors
by: Zimmermann Karel, et al.
Published: (2010-01-01)

A straightforward synthesis of 3-substituted azetidinic amino acids
by: Mangaleswaran Sivaprakasham, et al.
Published: (2006-12-01)

Cannot write session to /tmp/vufind_sessions/sess_tungemuffdadm2rkul3l1r0gf4