Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain

Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain

Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes...

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Main Authors: Andrés D. Maturana, Toshitsugu Fujita, Shun'ichi Kuroda
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2010.151
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spelling doaj-25f2a2eb5e364ea08f17f2da2f8f8af92020-11-25T00:59:44ZengHindawi LimitedThe Scientific World Journal1537-744X2010-01-01101646165410.1100/tsw.2010.151Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the BrainAndrés D. Maturana0Toshitsugu Fujita1Shun'ichi Kuroda2Department of Bioengineering, Nagaoka University of Technology, Niigata, JapanResearch Institute for Microbial Diseases, Osaka University, Osaka, JapanGraduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, JapanFasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. Recently, proteomic techniques revealed that FEZ1 interacts with various intracellular partners, such as signaling, motor, and structural proteins. FEZ1 was shown to act as an antiviral factor. The findings reported so far indicate that FEZ1 is associated with neuronal development, neuropathologies, and viral infection. Based on these accumulating evidences, we herein review the biological functions of FEZ1.http://dx.doi.org/10.1100/tsw.2010.151
collection DOAJ
language English
format Article
sources DOAJ
author Andrés D. Maturana
Toshitsugu Fujita
Shun'ichi Kuroda
spellingShingle Andrés D. Maturana
Toshitsugu Fujita
Shun'ichi Kuroda
Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
The Scientific World Journal
author_facet Andrés D. Maturana
Toshitsugu Fujita
Shun'ichi Kuroda
author_sort Andrés D. Maturana
title Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
title_short Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
title_full Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
title_fullStr Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
title_full_unstemmed Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain
title_sort functions of fasciculation and elongation protein zeta-1 (fez1) in the brain
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2010-01-01
description Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. Recently, proteomic techniques revealed that FEZ1 interacts with various intracellular partners, such as signaling, motor, and structural proteins. FEZ1 was shown to act as an antiviral factor. The findings reported so far indicate that FEZ1 is associated with neuronal development, neuropathologies, and viral infection. Based on these accumulating evidences, we herein review the biological functions of FEZ1.
url http://dx.doi.org/10.1100/tsw.2010.151
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