A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a molecular switch in TM6/7 of Class F receptor...
Full description
Bibliographic Details
| Main Authors: |
Shane C. Wright,
Paweł Kozielewicz,
Maria Kowalski-Jahn,
Julian Petersen,
Carl-Fredrik Bowin,
Greg Slodkowicz,
Maria Marti-Solano,
David Rodríguez,
Belma Hot,
Najeah Okashah,
Katerina Strakova,
Jana Valnohova,
M. Madan Babu,
Nevin A. Lambert,
Jens Carlsson,
Gunnar Schulte |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2019-02-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-019-08630-2
|
|---|
