Antagonistic Effects of IL-4 on IL-17A-Mediated Enhancement of Epidermal Tight Junction Function

Antagonistic Effects of IL-4 on IL-17A-Mediated Enhancement of Epidermal Tight Junction Function

Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease. AD is typically characterized by skewed T helper (Th) 2 inflammation, yet other inflammatory profiles (Th1, Th17, Th22) have been observed in human patients. How cytokines from these different Th subsets impac...

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Bibliographic Details
Main Authors: Matthew G. Brewer, Takeshi Yoshida, Fiona I. Kuo, Sade Fridy, Lisa A. Beck, Anna De Benedetto
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
atopic dermatitis
tight junctions
cytokines
claudin
STAT3
Online Access:https://www.mdpi.com/1422-0067/20/17/4070

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