Depressive symptoms and neurotrophin levels in ostomy patients

• Main Authors: Daniela Vicente Bavaresco, Mágada Tessmann Schwalm, Luciano Kurtz Jornada, Luiz Felipe Andrade Quadros, Bruna Simon, Luciane Bisognin Ceretta, Karina Cardoso Gulbis Zimmermann, Maria Inês da Rosa, Samira Silva Valvassori
• Format: Article
• Language: English
• Published: Universidade Federal do Rio de Janeiro
• Series: Jornal Brasileiro de Psiquiatria
• Subjects: Ostomy; BDNF; NGF; NT-3; depression
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852018000300166&lng=en&tlng=en

ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients.