Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders

Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders

The prediction of peptide binders to Major Histocompatibility Complex (MHC) class II receptors is of great interest to study autoimmune diseases and for vaccine development. Most approaches predict the affinities using sequence-based models trained on experimental data and multiple alignments from k...

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Bibliographic Details
Main Authors: Rodrigo Ochoa, Roman A. Laskowski, Janet M. Thornton, Pilar Cossio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
MHC class II
single-point mutation
structural bioinformatics
simulations
binding
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.636562/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.636562/full

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