Brain hyperserotonemia causes autism-relevant social deficits in mice

Brain hyperserotonemia causes autism-relevant social deficits in mice

Abstract Background Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods We analyzed behavior and gene expression to unveil th...

Full description

Bibliographic Details
Main Authors: Miho Tanaka, Atsushi Sato, Shinya Kasai, Yoko Hagino, Hiroko Kotajima-Murakami, Hirofumi Kashii, Yukio Takamatsu, Yasumasa Nishito, Masumi Inagaki, Masashi Mizuguchi, F. Scott Hall, George R. Uhl, Dennis Murphy, Ichiro Sora, Kazutaka Ikeda
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Autism
Subjects:
Serotonin transporter
Tryptophan depletion
Autism spectrum disorder
Heterozygous mice
Online Access:http://link.springer.com/article/10.1186/s13229-018-0243-3

Internet

http://link.springer.com/article/10.1186/s13229-018-0243-3

Similar Items