Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila

Sensory cues relevant to a food source, such as odors, can be associated with post-ingestion signals related either to food energetic value or toxicity. Despite numerous behavioral studies, a global understanding of the mechanisms underlying these long delay associations remains out of reach. Here,...

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Main Authors: Pierre-Yves Musso, Paul Tchenio, Thomas Preat
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715000613
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spelling doaj-25b868cbc7c440ada5f6b02252e1d5262020-11-25T01:02:29ZengElsevierCell Reports2211-12472015-02-011071023103110.1016/j.celrep.2015.01.036Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in DrosophilaPierre-Yves Musso0Paul Tchenio1Thomas Preat2Genes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, ESPCI-ParisTech, PSL Research University, 75005 Paris, FranceGenes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, ESPCI-ParisTech, PSL Research University, 75005 Paris, FranceGenes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, ESPCI-ParisTech, PSL Research University, 75005 Paris, FranceSensory cues relevant to a food source, such as odors, can be associated with post-ingestion signals related either to food energetic value or toxicity. Despite numerous behavioral studies, a global understanding of the mechanisms underlying these long delay associations remains out of reach. Here, we demonstrate in Drosophila that the long-term association between an odor and a nutritious sugar depends on delayed post-ingestion signaling of energy level. We show at the neural circuit level that the activity of two pairs of dopaminergic neurons is necessary and sufficient to signal energy level to the olfactory memory center. Accordingly, we have identified in these dopaminergic neurons a delayed calcium trace that correlates with appetitive long-term memory formation. Altogether, these findings demonstrate that the Drosophila brain remembers food quality through a two-step mechanism that consists of the integration of olfactory and gustatory sensory information and then post-ingestion energetic value.http://www.sciencedirect.com/science/article/pii/S2211124715000613
collection DOAJ
language English
format Article
sources DOAJ
author Pierre-Yves Musso
Paul Tchenio
Thomas Preat
spellingShingle Pierre-Yves Musso
Paul Tchenio
Thomas Preat
Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila
Cell Reports
author_facet Pierre-Yves Musso
Paul Tchenio
Thomas Preat
author_sort Pierre-Yves Musso
title Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila
title_short Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila
title_full Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila
title_fullStr Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila
title_full_unstemmed Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila
title_sort delayed dopamine signaling of energy level builds appetitive long-term memory in drosophila
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2015-02-01
description Sensory cues relevant to a food source, such as odors, can be associated with post-ingestion signals related either to food energetic value or toxicity. Despite numerous behavioral studies, a global understanding of the mechanisms underlying these long delay associations remains out of reach. Here, we demonstrate in Drosophila that the long-term association between an odor and a nutritious sugar depends on delayed post-ingestion signaling of energy level. We show at the neural circuit level that the activity of two pairs of dopaminergic neurons is necessary and sufficient to signal energy level to the olfactory memory center. Accordingly, we have identified in these dopaminergic neurons a delayed calcium trace that correlates with appetitive long-term memory formation. Altogether, these findings demonstrate that the Drosophila brain remembers food quality through a two-step mechanism that consists of the integration of olfactory and gustatory sensory information and then post-ingestion energetic value.
url http://www.sciencedirect.com/science/article/pii/S2211124715000613
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AT paultchenio delayeddopaminesignalingofenergylevelbuildsappetitivelongtermmemoryindrosophila
AT thomaspreat delayeddopaminesignalingofenergylevelbuildsappetitivelongtermmemoryindrosophila
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