Light-Induced Thiol Oxidation of Recoverin Affects Rhodopsin Desensitization

Light-Induced Thiol Oxidation of Recoverin Affects Rhodopsin Desensitization

The excessive light illumination of mammalian retina is known to induce oxidative stress and photoreceptor cell death linked to progression of age-related macular degeneration. The photochemical damage of photoreceptors is suggested to occur via two apoptotic pathways that involve either excessive r...

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Bibliographic Details
Main Authors: Evgeni Yu. Zernii, Aliya A. Nazipova, Ekaterina L. Nemashkalova, Alexey S. Kazakov, Olga S. Gancharova, Marina V. Serebryakova, Natalya K. Tikhomirova, Viktoriia E. Baksheeva, Vasiliy I. Vladimirov, Dmitry V. Zinchenko, Pavel P. Philippov, Ivan I. Senin, Sergei E. Permyakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
light-induced retinal damage
photoreceptor
apoptosis
neuronal calcium sensor
recoverin
thiol oxidation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00474/full

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