Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism

Turner syndrome (TS) with 45,X/46,XY mosaic karyotype is a rare sex chromosome disorder with an occurrence of 0.15‰ at birth. We report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a Chinese adult male with 45,X/46,XY mosaicism. The iPSC l...

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Main Authors:	Yumei Luo, Detu Zhu, Xiangye Xu, Lingxia Ge, Xiaofang Sun, Guokai Chen, Yaoyong Chen
Format:	Article
Language:	English
Published:	Elsevier 2018-03-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506118300035

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spelling	doaj-25b3889d97ea41f98ae16dc44ef19d562020-11-25T00:17:40ZengElsevierStem Cell Research1873-50612018-03-01274245Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicismYumei Luo0Detu Zhu1Xiangye Xu2Lingxia Ge3Xiaofang Sun4Guokai Chen5Yaoyong Chen6Key Laboratory for Major Obstetric Diseases of Guangdong Province; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USAKey Laboratory for Major Obstetric Diseases of Guangdong Province; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaKey Laboratory for Major Obstetric Diseases of Guangdong Province; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaKey Laboratory for Major Obstetric Diseases of Guangdong Province; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaFaculty of Health Sciences, University of Macau, Macau 999078, China; National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USAKey Laboratory for Major Obstetric Diseases of Guangdong Province; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China; Corresponding author.Turner syndrome (TS) with 45,X/46,XY mosaic karyotype is a rare sex chromosome disorder with an occurrence of 0.15‰ at birth. We report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a Chinese adult male with 45,X/46,XY mosaicism. The iPSC line retains the original 45,X/46,XY mosaic karyotype, expresses pluripotency markers and undergoes trilineage differentiation. Therefore, it offers an unprecedented cellular model to investigate the profound symptoms like infertility of TS in the male, and serve as a useful tool to develop therapies for the disease.http://www.sciencedirect.com/science/article/pii/S1873506118300035
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yumei Luo Detu Zhu Xiangye Xu Lingxia Ge Xiaofang Sun Guokai Chen Yaoyong Chen
spellingShingle	Yumei Luo Detu Zhu Xiangye Xu Lingxia Ge Xiaofang Sun Guokai Chen Yaoyong Chen Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism Stem Cell Research
author_facet	Yumei Luo Detu Zhu Xiangye Xu Lingxia Ge Xiaofang Sun Guokai Chen Yaoyong Chen
author_sort	Yumei Luo
title	Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
title_short	Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
title_full	Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
title_fullStr	Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
title_full_unstemmed	Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
title_sort	generation of an induced pluripotent stem cell line from an adult male with 45,x/46,xy mosaicism
publisher	Elsevier
series	Stem Cell Research
issn	1873-5061
publishDate	2018-03-01
description	Turner syndrome (TS) with 45,X/46,XY mosaic karyotype is a rare sex chromosome disorder with an occurrence of 0.15‰ at birth. We report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a Chinese adult male with 45,X/46,XY mosaicism. The iPSC line retains the original 45,X/46,XY mosaic karyotype, expresses pluripotency markers and undergoes trilineage differentiation. Therefore, it offers an unprecedented cellular model to investigate the profound symptoms like infertility of TS in the male, and serve as a useful tool to develop therapies for the disease.
url	http://www.sciencedirect.com/science/article/pii/S1873506118300035
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Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism

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