Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.

Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.

The phenoxyalkylimidazoles (PAI) are an attractive chemical series with potent anti-tubercular activity targeting Mycobacterium tuberculosis respiration. Our aim was to determine if the PAI compounds are subject to efflux. Two analogs containing an oxadiazole had improved potency in the presence of...

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Main Authors: Mai B Thayer, Tanya Parish
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239353
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spelling doaj-25b2c70aa2d34212a6321f3eed7513e42021-05-03T04:30:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e023935310.1371/journal.pone.0239353Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.Mai B ThayerTanya ParishThe phenoxyalkylimidazoles (PAI) are an attractive chemical series with potent anti-tubercular activity targeting Mycobacterium tuberculosis respiration. Our aim was to determine if the PAI compounds are subject to efflux. Two analogs containing an oxadiazole had improved potency in the presence of the efflux inhibitors reserpine and carbonyl cyanide m-chlorophenylhydrazine, whereas the potency of analogs with a diazole was not affected.https://doi.org/10.1371/journal.pone.0239353
collection DOAJ
language English
format Article
sources DOAJ
author Mai B Thayer
Tanya Parish
spellingShingle Mai B Thayer
Tanya Parish
Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
PLoS ONE
author_facet Mai B Thayer
Tanya Parish
author_sort Mai B Thayer
title Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
title_short Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
title_full Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
title_fullStr Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
title_full_unstemmed Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis.
title_sort phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in mycobacterium tuberculosis.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2021-01-01
description The phenoxyalkylimidazoles (PAI) are an attractive chemical series with potent anti-tubercular activity targeting Mycobacterium tuberculosis respiration. Our aim was to determine if the PAI compounds are subject to efflux. Two analogs containing an oxadiazole had improved potency in the presence of the efflux inhibitors reserpine and carbonyl cyanide m-chlorophenylhydrazine, whereas the potency of analogs with a diazole was not affected.
url https://doi.org/10.1371/journal.pone.0239353
work_keys_str_mv AT maibthayer phenoxyalkylimidazoleswithanoxadiazolemoietyaresubjecttoeffluxinmycobacteriumtuberculosis
AT tanyaparish phenoxyalkylimidazoleswithanoxadiazolemoietyaresubjecttoeffluxinmycobacteriumtuberculosis
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