Alcohol enhances Acinetobacter baumannii-associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection.

Alcohol enhances Acinetobacter baumannii-associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection.

Acinetobacter baumannii (Ab) is a common cause of community-acquired pneumonia (CAP) in chronic alcoholics in tropical and sub-tropical climates and associated with a >50% mortality rate. Using a murine model of alcohol (EtOH) administration, we demonstrated that EtOH enhances Ab-mediated pneumon...

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Bibliographic Details
Main Authors: Jay A Gandhi, Vaibhav V Ekhar, Melissa B Asplund, Asan F Abdulkareem, Mohammed Ahmadi, Carolina Coelho, Luis R Martinez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3994102?pdf=render

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http://europepmc.org/articles/PMC3994102?pdf=render

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