Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism

Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism

Summary: Aging-associated functional decline is accompanied by alterations in the epigenome. To explore DNA modifications that could influence visual function with age, we perform whole-genome bisulfite sequencing of purified mouse rod photoreceptors at four ages and identify 2,054 differentially me...

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Main Authors: Ximena Corso-Díaz, James Gentry, Ryan Rebernick, Catherine Jaeger, Matthew J. Brooks, Freekje van Asten, Keshav Kooragayala, Linn Gieser, Jacob Nellissery, Raul Covian, Tiziana Cogliati, Anupam K. Mondal, Ke Jiang, Anand Swaroop
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720304253

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http://www.sciencedirect.com/science/article/pii/S2211124720304253

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