Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system

Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system

A novel flow injection chemiluminescence (CL) method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO4, and Na2SO3 in acid media. The CL intensity of KMnO4-Na2SO3 was greatly enhaneed in the presence of loxoprofen and naproxen. The mechanism of the CL reac...

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Main Authors: Li-Juan Wang, Yu-Hai Tang, Yang-Hao Liu
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177911700090
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spelling doaj-25ab6ba348644e8581e7d89f09cb4bbe2021-04-02T06:35:23ZengElsevierJournal of Pharmaceutical Analysis2095-17792011-02-01115156Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite systemLi-Juan Wang0Yu-Hai Tang1Yang-Hao Liu2Medical School, Xiâan Jiaotong University, Xiâan 710061, China; Institute of Analytical Sciences, Xiâan Jiaotong University, Xiâan 710061, ChinaInstitute of Analytical Sciences, Xiâan Jiaotong University, Xiâan 710061, China; Corrcsponding author.Institute of Analytical Sciences, Xiâan Jiaotong University, Xiâan 710061, ChinaA novel flow injection chemiluminescence (CL) method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO4, and Na2SO3 in acid media. The CL intensity of KMnO4-Na2SO3 was greatly enhaneed in the presence of loxoprofen and naproxen. The mechanism of the CL reaction was studied by the kinetic proecss and UV-vis absorption and the conditions were optimized. Under optimized conditions, the CL intensity was linear with loxoprofen and naproxen concentration in the range of 7.0 Ã 10â8 â 1.0 Ã 10â5 g/mL and 2.0 Ã 10â7 â 4.0 Ã 10â6 g/mL with the detection limit of 2.0 Ã 10â8 g/mL and 3.0 Ã 10â8 g/mL (S/N = 3), respectively. Thc relative standard deviations were 2.39% and 1.37% for 5.0 Ã 10â7 g/mL naproxen and 5.0 Ã 10â7 g/mL loxoprofen (n = 10), respectively. The proposed method was satisfactorily applied to thc determination of loxoprofen and naproxen in pharmaceutical preparations. Keywords: chemiluminescence, KMnO4, loxoprofen, naproxenhttp://www.sciencedirect.com/science/article/pii/S2095177911700090
collection DOAJ
language English
format Article
sources DOAJ
author Li-Juan Wang
Yu-Hai Tang
Yang-Hao Liu
spellingShingle Li-Juan Wang
Yu-Hai Tang
Yang-Hao Liu
Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
Journal of Pharmaceutical Analysis
author_facet Li-Juan Wang
Yu-Hai Tang
Yang-Hao Liu
author_sort Li-Juan Wang
title Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
title_short Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
title_full Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
title_fullStr Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
title_full_unstemmed Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
title_sort flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
publisher Elsevier
series Journal of Pharmaceutical Analysis
issn 2095-1779
publishDate 2011-02-01
description A novel flow injection chemiluminescence (CL) method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO4, and Na2SO3 in acid media. The CL intensity of KMnO4-Na2SO3 was greatly enhaneed in the presence of loxoprofen and naproxen. The mechanism of the CL reaction was studied by the kinetic proecss and UV-vis absorption and the conditions were optimized. Under optimized conditions, the CL intensity was linear with loxoprofen and naproxen concentration in the range of 7.0 Ã 10â8 â 1.0 Ã 10â5 g/mL and 2.0 Ã 10â7 â 4.0 Ã 10â6 g/mL with the detection limit of 2.0 Ã 10â8 g/mL and 3.0 Ã 10â8 g/mL (S/N = 3), respectively. Thc relative standard deviations were 2.39% and 1.37% for 5.0 Ã 10â7 g/mL naproxen and 5.0 Ã 10â7 g/mL loxoprofen (n = 10), respectively. The proposed method was satisfactorily applied to thc determination of loxoprofen and naproxen in pharmaceutical preparations. Keywords: chemiluminescence, KMnO4, loxoprofen, naproxen
url http://www.sciencedirect.com/science/article/pii/S2095177911700090
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AT yuhaitang flowinjectionchemiluminescencedeterminationofloxoprofenandnaproxenwiththeacidicpermanganatesulfitesystem
AT yanghaoliu flowinjectionchemiluminescencedeterminationofloxoprofenandnaproxenwiththeacidicpermanganatesulfitesystem
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