UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.

UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.

Elucidation of the molecular cues required to balance adult stem cell self-renewal and differentiation is critical for advancing cellular therapies. Herein, we report that the hematopoietic stem cell (HSC) self-renewal agonist UM171 triggers a balanced pro- and anti-inflammatory/detoxification netwo...

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Bibliographic Details
Main Authors: Jalila Chagraoui, Bernhard Lehnertz, Simon Girard, Jean Francois Spinella, Iman Fares, Elisa Tomellini, Nadine Mayotte, Sophie Corneau, Tara MacRae, Laura Simon, Guy Sauvageau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0224900

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https://doi.org/10.1371/journal.pone.0224900

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