A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging

A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging

Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H2S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H2S...

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Bibliographic Details
Main Authors: Rongchen Wang, Wei Gao, Jie Gao, Ge Xu, Tianli Zhu, Xianfeng Gu, Chunchang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
ratiometric
light up
FRET
AIE
NIR-II imaging
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00778/full
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spelling doaj-25949cb9e73b45aaad95a8df4037bba72020-11-24T22:08:19ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-11-01710.3389/fchem.2019.00778488178A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for BioimagingRongchen Wang0Wei Gao1Jie Gao2Ge Xu3Tianli Zhu4Xianfeng Gu5Chunchang Zhao6Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, ChinaKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, ChinaKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, ChinaKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, ChinaKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, ChinaReal-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H2S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H2S-responsive site. Such a designed probe showed H2S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H2S-rich cancer cells and identification of H2S-rich tumors with high resolution.https://www.frontiersin.org/article/10.3389/fchem.2019.00778/fullratiometriclight upFRETAIENIR-II imaging
collection DOAJ
language English
format Article
sources DOAJ
author Rongchen Wang
Wei Gao
Jie Gao
Ge Xu
Tianli Zhu
Xianfeng Gu
Chunchang Zhao
spellingShingle Rongchen Wang
Wei Gao
Jie Gao
Ge Xu
Tianli Zhu
Xianfeng Gu
Chunchang Zhao
A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
Frontiers in Chemistry
ratiometric
light up
FRET
AIE
NIR-II imaging
author_facet Rongchen Wang
Wei Gao
Jie Gao
Ge Xu
Tianli Zhu
Xianfeng Gu
Chunchang Zhao
author_sort Rongchen Wang
title A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
title_short A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
title_full A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
title_fullStr A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
title_full_unstemmed A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging
title_sort förster resonance energy transfer switchable fluorescent probe with h2s-activated second near-infrared emission for bioimaging
publisher Frontiers Media S.A.
series Frontiers in Chemistry
issn 2296-2646
publishDate 2019-11-01
description Real-time and accurate detection of endogenous hydrogen sulfide is of great biomedical significance. Here, a FRET-based fluorescent probe for ratiometric detection of H2S was designed to comprise an AIE luminophore TPE as an energy donor and a monochlorinated BODIPY dye as an energy acceptor and H2S-responsive site. Such a designed probe showed H2S-dependent ratiometric and light-up NIR-II emission, enabling accurate imaging of H2S-rich cancer cells and identification of H2S-rich tumors with high resolution.
topic ratiometric
light up
FRET
AIE
NIR-II imaging
url https://www.frontiersin.org/article/10.3389/fchem.2019.00778/full
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