Application of PSMA PET/CT Specific Molecular Imaging in Diagnosis of Non-prostate Cancer

• Main Authors: LIU Teli, LIU Chen, ZHANG Yuqi, DENG Yujiao, ZHU Hua, YANG Zhi
• Format: Article
• Language: zho
• Published: Magazine House of Cancer Research on Prevention and Treatment 2019-11-01
• Series: Zhongliu Fangzhi Yanjiu
• Subjects: prostate specific membrane antigen(psma); pet/ct; non-prostate cancer
• Online Access: http://html.rhhz.net/ZLFZYJ/html/8578.2019.19.0356.htm

Prostate specific membrane antigen(PSMA) is a glutamate carboxypeptidase Ⅱ secreted by the epithelial cells of prostate gland. PSMA is over-expressed in the cells of prostate cancer and metastases, and also positively expressed in the tumor-related neovascular endothelial cells. Therefore, more than twenty PSMA-targeted probes had been used for the diagnosis and therapy of prostate cancer. This article reviews the expression of PSMA in non-prostate cancer and the clinical application of PSMA-PET/CT specific probes in detecting non-prostate cancer, to expand the clinical application of novel PSMA-targeted PET probes in the diagnosis of tumors.