Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

Metformin, apart from its glucose-lowering properties, has also been found to demonstrate anti-cancer properties. Anti-cancer efficacy of metformin depends on its uptake in cancer cells, which is mediated by plasma membrane monoamine transporters (PMAT) and organic cation transporters (OCTs). This s...

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Bibliographic Details
Main Authors: Magdalena Markowicz-Piasecka, Karol Sadowski, Johanna Huttunen, Joanna Sikora, Kristiina M. Huttunen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
metformin
sulfonamides
apoptosis
cellular uptake
cell cycle arrest
Online Access:https://www.mdpi.com/1422-0067/22/11/5642

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