Perfused human organs versus Mary Shelley's Frankenstein
<p>Abstract</p> <p>Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects s...
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2009-01-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/7/1/9 |
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doaj-258260c6120449ce9666da4c34d169db2020-11-24T22:22:35ZengBMCJournal of Translational Medicine1479-58762009-01-0171910.1186/1479-5876-7-9Perfused human organs versus Mary Shelley's FrankensteinLeung Lawrence<p>Abstract</p> <p>Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects seen <it>in vitro </it>often do not translate to <it>in vivo </it>human settings. The search is on for better models closer to human physiology to be used in pre-clinical drug screening. The Ex Vivo Metrics<sup>© </sup>system has been introduced where a human organ is harvested and revitalized in a controlled environment suitable for testing of both drug efficacy and potential toxicity. This commentary expresses the author's views regarding this technology of perfused human organs.</p> http://www.translational-medicine.com/content/7/1/9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Leung Lawrence |
| spellingShingle |
Leung Lawrence Perfused human organs versus Mary Shelley's Frankenstein Journal of Translational Medicine |
| author_facet |
Leung Lawrence |
| author_sort |
Leung Lawrence |
| title |
Perfused human organs versus Mary Shelley's Frankenstein |
| title_short |
Perfused human organs versus Mary Shelley's Frankenstein |
| title_full |
Perfused human organs versus Mary Shelley's Frankenstein |
| title_fullStr |
Perfused human organs versus Mary Shelley's Frankenstein |
| title_full_unstemmed |
Perfused human organs versus Mary Shelley's Frankenstein |
| title_sort |
perfused human organs versus mary shelley's frankenstein |
| publisher |
BMC |
| series |
Journal of Translational Medicine |
| issn |
1479-5876 |
| publishDate |
2009-01-01 |
| description |
<p>Abstract</p> <p>Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects seen <it>in vitro </it>often do not translate to <it>in vivo </it>human settings. The search is on for better models closer to human physiology to be used in pre-clinical drug screening. The Ex Vivo Metrics<sup>© </sup>system has been introduced where a human organ is harvested and revitalized in a controlled environment suitable for testing of both drug efficacy and potential toxicity. This commentary expresses the author's views regarding this technology of perfused human organs.</p> |
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http://www.translational-medicine.com/content/7/1/9 |
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