Perfused human organs versus Mary Shelley's Frankenstein
<p>Abstract</p> <p>Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects s...
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| Format: | Article |
| Language: | English |
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BMC
2009-01-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/7/1/9 |
| Summary: | <p>Abstract</p> <p>Novel drugs have to go through mandatory pre-clinical testing before they can be approved for use in clinical trials. In essence, it is a form of bench-to-bedside (N2B) translational medicine, but the wastage rate of target candidates is immensely high. Effects seen <it>in vitro </it>often do not translate to <it>in vivo </it>human settings. The search is on for better models closer to human physiology to be used in pre-clinical drug screening. The Ex Vivo Metrics<sup>© </sup>system has been introduced where a human organ is harvested and revitalized in a controlled environment suitable for testing of both drug efficacy and potential toxicity. This commentary expresses the author's views regarding this technology of perfused human organs.</p> |
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| ISSN: | 1479-5876 |