Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection.

Rac2-deficiency leads to exacerbated and protracted colitis in response to Citrobacter rodentium infection.

Recent genetic-based studies have implicated a number of immune-related genes in the pathogenesis of inflammatory bowel disease (IBD). Our recent genetic studies showed that RAC2 is associated with human IBD; however, its role in disease pathogenesis is unclear. Given Rac2's importance in vario...

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Bibliographic Details
Main Authors: Ramzi Fattouh, Cong-Hui Guo, Grace Y Lam, Melanie G Gareau, Bo-Yee Ngan, Michael Glogauer, Aleixo M Muise, John H Brumell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3628927?pdf=render

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