Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells.

Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells.

Artonin E is a prenylated flavonoid isolated from the stem bark of Artocarpus elasticus Reinw.(Moraceae). This study aimed to investigate the apoptotic mechanisms induced by artonin E in a metastatic human ovarian cancer cell line SKOV-3 in vitro. MTT assay, clonogenic assay, acridine orange and pro...

Full description

Bibliographic Details
Main Authors:	Mashitoh Abd Rahman, Faiqah Ramli, Hamed Karimian, Firouzeh Dehghan, Noraziah Nordin, Hapipah Mohd Ali, Syam Mohan, Najihah Mohd Hashim
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4809498?pdf=render

Similar Items

Ultrastructural Study on the Antibacterial Activity of Artonin E versus Streptomycin against Staphylococcus aureus Strains.
by: Asdren Zajmi, et al.
Published: (2015-01-01)

Reduction of breast tumor burden in mice by a prenylated flavonoid, Artonin E
by: Etti, Imaobong Christopher, et al.
Published: (2017)

Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway.
by: Noraziah Nordin, et al.
Published: (2016-01-01)

The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
by: Etti, Imaobong Christopher, et al.
Published: (2017)

The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells.
by: Imaobong Christopher Etti, et al.
Published: (2017-01-01)

Artonin E and Structural Analogs from Artocarpus Species Abrogates Estrogen Receptor Signaling in Breast Cancer
by: Imaobong Etti, et al.
Published: (2016-06-01)

Isolation of Artonin E from the root bark of Artocarpus rigida, synthesis of Artonin E acetate and evaluation of anticancer activity
by: Tati Suhartati, et al.
Published: (2018-06-01)

Biotransformation of artonin E by locally isolated microorganisms
by: Lai, Yew Seng
Published: (2013)

Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3)
by: Aneta Rogalska, et al.
Published: (2018-09-01)

Antioxidant, anticancer and antimicrobial activities of methanolic extracts from enicosanthellum pulchrum (King) heusden
by: Noraziah Nordin, et al.
Published: (2014)

Inhibition of ovarian cancer cell line SKOV3 with AC-0
by: Tai-Jung Tsai, et al.
Published: (2015)

Anti-cancer effects of Kaempferia parviflora on ovarian cancer SKOV3 cells
by: Suthasinee Paramee, et al.
Published: (2018-06-01)

Apoptotic and genomic effects of corilagin on SKOV3 ovarian cancer cell line
by: Attar R, et al.
Published: (2017-03-01)

Beta-mangostin from activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G/G cell-cycle arrest
by: Fatima Abdelmutaal Ahmed Omer, et al.
Published: (2017-10-01)

Enhancement of radiation response by K1 in human ovarian carcinoma SKOV-3 cells
by: Yen-Jung Chen, et al.
Published: (2008)

Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin
by: Shahana Dilruba, et al.
Published: (2020-02-01)

Effects of Digoxin and Digitoxin on the Growth of Human Ovarian Cancer Cell Line SKOV-3
by: Jie-Hau Li, et al.
Published: (2014)

The Role of Lysophosphatidic Acid in Ovarian Cancer SKOV3 Cell Dispersal and Junction Disruption
by: Yun-Ju Huang, et al.
Published: (2008)

Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo
by: Fatima Abdelmutaal Ahmed Omer, et al.
Published: (2017-07-01)

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity Against SKOV-3 Ovarian Cancer Cells
by: Usama A. Fahmy, et al.
Published: (2021-12-01)

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3
by: Heba Almosa, et al.
Published: (2020-03-01)

Cytotoxicity and Transcriptomic Analyses of Biogenic Palladium Nanoparticles in Human Ovarian Cancer Cells (SKOV3)
by: Sangiliyandi Gurunathan, et al.
Published: (2019-05-01)

The Effect of Triptolide-Loaded Exosomes on the Proliferation and Apoptosis of Human Ovarian Cancer SKOV3 Cells
by: Huan Liu, et al.
Published: (2019-01-01)

Effect of Daidzein in HER2 over-expressing human ovarian carcinoma SKOV3 cell
by: Chun-Ko Chen, et al.
Published: (2009)

Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells
by: Ling Xu, et al.
Published: (2014-01-01)

Molecular docking study of naturally derived flavonoids with antiapoptotic BCL-2 and BCL-XL proteins toward ovarian cancer treatment
by: Mohd Faiz Abd Ghani, et al.
Published: (2020-01-01)

Effect of ovarian cancer ascites on SKOV-3 cells proteome: new proteins associated with aggressive phenotype in epithelial ovarian cancer
by: Alfredo Toledo-Leyva, et al.
Published: (2018-02-01)

The human amniotic fluid mesenchymal stem cells therapy on, SKOV3, ovarian cancer cell line
by: Shiva Gholizadeh‐Ghaleh Aziz, et al.
Published: (2019-07-01)

Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3
by: Galyna Shuvayeva, et al.
Published: (2014-01-01)

MMP-3 Expression and its Effect on the Invasion and Proliferation in Ovarian Cancer Cell Line SKOV-3
by: Tze-Chien Chen, et al.
Published: (2007)

Analysis of estrogen mediated inhibition of migration and invasion in human SKOV3 ovarian cancer cell line
by: Chi-Hau Chen, et al.
Published: (2004)

Effect and Molecular Mechanism of MFG-E8 on Sensitivity of Ovarian Cancer SKOV3 Cells to Cisplatin
by: LI Na, et al.
Published: (2021-05-01)

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3
by: Jou-Chun Chou, et al.
Published: (2021-03-01)

Monobenzyltin Complex C1 Induces Apoptosis in MCF-7 Breast Cancer Cells through the Intrinsic Signaling Pathway and through the Targeting of MCF-7-Derived Breast Cancer Stem Cells via the Wnt/β-Catenin Signaling Pathway.
by: Somayeh Fani, et al.
Published: (2016-01-01)

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
by: Suvitha Syam, et al.
Published: (2014-01-01)

Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway
by: Li-qian Zhang, et al.
Published: (2017-01-01)

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
by: Etti IC, et al.
Published: (2017-03-01)

In vitro assessment of anti-proliferative effect induced by α-mangostin from Cratoxylum arborescens on HeLa cells
by: Aisha I. El habbash, et al.
Published: (2017-07-01)

In vitro assessment of anti-proliferative effect induced by alpha-mangostin from Cratoxylum arborescens on HeLa cells
by: El Habbash, Aisha I., et al.
Published: (2017)

The reversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin on SKOV3/DDP ovarian carcinoma cells
by: Zhi Jiang, et al.
Published: (2009-04-01)