Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors

The development of isoform selective inhibitors of the carbonic anhydrase (CA; EC 4.2.1.1) enzymes represents the key approach for the successful development of druggable small molecules. Herein we report a series of new benzenesulfamide derivatives (-NH-SO2NH2) bearing the 1-benzhydrylpiperazine ta...

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Bibliographic Details
Main Authors: Emanuela Berrino, Silvia Bua, Mattia Mori, Maurizio Botta, Vallabhaneni S. Murthy, Vijayaparthasarathi Vijayakumar, Yasinalli Tamboli, Gianluca Bartolucci, Alessandro Mugelli, Elisabetta Cerbai, Claudiu T. Supuran, Fabrizio Carta
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
carbonic anhydrase inhibitors (CAIs)
sulfamides
structure-activity-relationship (SAR)
Online Access:http://www.mdpi.com/1420-3049/22/7/1049

Internet

http://www.mdpi.com/1420-3049/22/7/1049

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