Substance P blockade effects on peripheral blood leukocytic reaction in secondary chronic inflammation

• Main Authors: O. M. Shevchenko, V. O. Sych
• Format: Article
• Language: English
• Published: Kazimierz Wielki University 2019-11-01
• Series: Journal of Education, Health and Sport
• Subjects: secondary chronic inflammation; peripheral blood; substance p; experiment; rats
• Online Access: https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/32771

<p class="1">In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of inflammation, at 6 hours there was a significant decrease in total white blood cells count by 1.28 (p&lt;0.05), as well as a significant decrease in the number of polymorphonuclear neutrophils by 4 times (p&lt;0.05) and the number of eosinophils by 3 times (p&lt;0.05) by 10 days. On day 28, there was a significant increase in the number of monocytes in 2 times (p&lt;0,01). The results of the study indicate that in natural conditions of inflammation, substance P stimulates blood leukocytes, as well as prolongs the inflammatory response, and its blocking helps to reduce the inflammatory response.</p>