Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells

Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells

Abstract Background Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a crucial role in various human diseases, but under orchitis, the role and und...

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Bibliographic Details
Main Authors: Xu Zhou, Jingliang He, Jinbo Chen, Yu Cui, Zhenyu Ou, Xiongbing Zu, Nenghui Liu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Reproductive Biology and Endocrinology
Subjects:
Orchitis
Leydig cell
LPS
MEG3
ceRNA
Online Access:https://doi.org/10.1186/s12958-021-00712-5

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