Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells

Genomic imprinting restricts transcription to predominantly one parental allele. Here the authors perform a screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse extraembryonic endoderm stem cells and characterize a role for specific nucleopor...

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Main Authors:	Saqib S. Sachani, Lauren S. Landschoot, Liyue Zhang, Carlee R. White, William A. MacDonald, Michael C. Golding, Mellissa R. W. Mann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05208-2

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spelling	doaj-25652c853649470992f3e868f9d71ef12021-05-11T09:32:33ZengNature Publishing GroupNature Communications2041-17232018-07-019111710.1038/s41467-018-05208-2Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cellsSaqib S. Sachani0Lauren S. Landschoot1Liyue Zhang2Carlee R. White3William A. MacDonald4Michael C. Golding5Mellissa R. W. Mann6Departments of Obstetrics & Gynaecology, and Biochemistry, Western University, Schulich School of Medicine and DentistryDepartments of Obstetrics & Gynaecology, and Biochemistry, Western University, Schulich School of Medicine and DentistryDepartments of Obstetrics & Gynaecology, and Biochemistry, Western University, Schulich School of Medicine and DentistryDepartments of Obstetrics & Gynaecology, and Biochemistry, Western University, Schulich School of Medicine and DentistryDepartments of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of MedicineDepartment of Veterinary Physiology, College of Veterinary Medicine, Texas A&M UniversityDepartments of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of MedicineGenomic imprinting restricts transcription to predominantly one parental allele. Here the authors perform a screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse extraembryonic endoderm stem cells and characterize a role for specific nucleoporins in mediating Kcnq1ot1 imprinted regulation.https://doi.org/10.1038/s41467-018-05208-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Saqib S. Sachani Lauren S. Landschoot Liyue Zhang Carlee R. White William A. MacDonald Michael C. Golding Mellissa R. W. Mann
spellingShingle	Saqib S. Sachani Lauren S. Landschoot Liyue Zhang Carlee R. White William A. MacDonald Michael C. Golding Mellissa R. W. Mann Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells Nature Communications
author_facet	Saqib S. Sachani Lauren S. Landschoot Liyue Zhang Carlee R. White William A. MacDonald Michael C. Golding Mellissa R. W. Mann
author_sort	Saqib S. Sachani
title	Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells
title_short	Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells
title_full	Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells
title_fullStr	Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells
title_full_unstemmed	Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells
title_sort	nucleoporin 107, 62 and 153 mediate kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	Genomic imprinting restricts transcription to predominantly one parental allele. Here the authors perform a screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse extraembryonic endoderm stem cells and characterize a role for specific nucleoporins in mediating Kcnq1ot1 imprinted regulation.
url	https://doi.org/10.1038/s41467-018-05208-2
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Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells

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