Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma

Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma

Abstract Glioma is one of the most lethal cancers with highly vascularized networks and growing evidences have identified glioma stem cells (GSCs) to account for excessive angiogenesis in glioma. Aberrant expression of paired-related homeobox1 (Prrx1) has been functionally associated with cancer ste...

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Bibliographic Details
Main Authors: Zetao Chen, Yihong Chen, Yan Li, Weidong Lian, Kehong Zheng, Yuxuan Zhang, Yujie Zhang, Chuang Lin, Chaoqun Liu, Fei Sun, Xinlin Sun, Jihui Wang, Liang Zhao, Yiquan Ke
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03882-7

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