Pathological and Molecular Characteristics of Colorectal Cancer with Brain Metastases

Pathological and Molecular Characteristics of Colorectal Cancer with Brain Metastases

<i>Background:</i> Colorectal cancers (CRC) with brain metastases (BM) are scarcely described. The main objective of this study was to determine the molecular profile of CRC with BM. <i>Methods:</i> We included 82 CRC patients with BM. <i>KRAS</i>, <i>NRAS&l...

Full description

Bibliographic Details
Main Authors:	Pauline Roussille, Gaelle Tachon, Claire Villalva, Serge Milin, Eric Frouin, Julie Godet, Antoine Berger, Sheik Emambux, Christos Petropoulos, Michel Wager, Lucie Karayan-Tapon, David Tougeron
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Series:	Cancers
Subjects:	brain metastases colorectal cancer <i>KRAS</i> mutation PD-L1 tumor infiltrating lymphocytes
Online Access:	https://www.mdpi.com/2072-6694/10/12/504

Similar Items

Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma
by: Sophie Richard, et al.
Published: (2020-09-01)

Evolution of Mutational Landscape and Tumor Immune-Microenvironment in Liver Oligo-Metastatic Colorectal Cancer
by: Alessandro Ottaiano, et al.
Published: (2020-10-01)

Analysis of factors influencing molecular testing at diagnostic of colorectal cancer
by: Quentin Thiebault, et al.
Published: (2017-11-01)

Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge
by: Audelaure Junca, et al.
Published: (2020-06-01)

Malignant melanoma - cutaneous metastases
by: Padmavathy L, et al.
Published: (2008-01-01)

Differential effects of KRAS mutational status on long-term survival according to the timing of colorectal liver metastases
by: Nozomu Sakai, et al.
Published: (2021-04-01)

Discordance of KRAS Mutational Status between Primary Tumors and Liver Metastases in Colorectal Cancer: Impact on Long-Term Survival Following Radical Resection
by: Francesco Ardito, et al.
Published: (2021-04-01)

Concordance of KRAS mutation status between luminal and peripheral regions of primary colorectal cancer. A laser-capture microdissection-based study
by: Magdalena Lewandowska, et al.
Published: (2016-05-01)

Quadruplicate Synchronous Adenocarcinoma of the Colon with Distant Metastases—Long-Term Molecular Follow-Up by KRAS and TP53 Mutational Profiling
by: Emese Sarolta Bádon, et al.
Published: (2020-06-01)

Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer
by: Camille Evrard, et al.
Published: (2019-10-01)

EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma
by: Roberto Chalela, et al.
Published: (2019-04-01)

Comparison of EGFR and KRAS Status between Primary Non-small Cell Lung Cancer and Corresponding Metastases: A Systematic Review and meta-analysis
by: Chengbo HAN, et al.
Published: (2010-09-01)

The value of KRAS gene status in predicting local tumor progression of colorectal liver metastases following radiofrequency ablation
by: Bin-bin Jiang, et al.
Published: (2019-01-01)

The Management of Brain Metastases—Systematic Review of Neurosurgical Aspects
by: Martin A. A. Proescholdt, et al.
Published: (2021-03-01)

Prognostic and Immunotherapeutic Roles of KRAS in Pan-Cancer
by: Gu, X., et al.
Published: (2022)

The Prognostic Effect of <i>KRAS</i> Mutations in Non-Small Cell Lung Carcinoma Revisited: A Norwegian Multicentre Study
by: Sissel Gyrid Freim Wahl, et al.
Published: (2021-08-01)

Immune Microenvironment of Brain Metastases—Are Microglia and Other Brain Macrophages Little Helpers?
by: Hua You, et al.
Published: (2019-08-01)

The Screening and COnsensus Based on Practices and Evidence (SCOPE) Program–Results of a Survey on Daily Practice Patterns for Patients with mCRC
by: Gerald Prager, et al.
Published: (2021-06-01)

K-Ras Peptide Mimotope Induces Antigen Specific Th1 and B-Cell Immune Responses against G12A-Mutated K-Ras Antigen in Balb/c Mice
by: Pui Yan Siak, et al.
Published: (2021-02-01)

Eicosapentaenoic Acid Inhibits <i>KRAS</i> Mutant PancreaticCancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation
by: Ching-Feng Chiu, et al.
Published: (2021-03-01)

Active Compound of <i>Pharbitis</i> Semen (<i>Pharbitis nil</i> Seeds) Suppressed KRAS-Driven Colorectal Cancer and Restored Muscle Cell Function during Cancer Progression
by: Jisu Song, et al.
Published: (2020-06-01)

Second-line panitumumab as a triweekly dose for patients with wild-type <i>KRAS</i> exon 2 metastatic colorectal cancer: a single-institution experience
by: Mohamed A. Daoud, et al.
Published: (2016-03-01)

KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy
by: Pinto Rosamaria, et al.
Published: (2019-08-01)

MiR-216b inhibits pancreatic cancer cell progression and promotes apoptosis by down-regulating KRAS
by: Xinquan Wu, et al.
Published: (2017-12-01)

Investigação da quinase IKKβ como um alvo terapêutico anti-metastático em câncer de pulmão associado à ativação do oncogene KRAS
by: Miranda, Vanessa Silva
Published: (2019)

High Intra- and Inter-Tumoral Heterogeneity of RAS Mutations in Colorectal Cancer
by: Marion Jeantet, et al.
Published: (2016-12-01)

Novel <i>Antrodia cinnamomea</i> Extract Reduced Cancer Stem-Like Phenotype Changes and Resensitized <i>KRAS</i>-Mutant Colorectal Cancer via a MicroRNA-27a Pathway
by: Tsung-Jen Lin, et al.
Published: (2019-10-01)

The Inhibition of Wnt Restrain KRAS<sup>G12V</sup>-Driven Metastasis in Non-Small-Cell Lung Cancer
by: Pei-Shan Hung, et al.
Published: (2020-03-01)

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases
by: Maarit Ahtiainen, et al.
Published: (2021-03-01)

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients
by: Jungang Liu, et al.
Published: (2021-01-01)

Protein Arginine Methyltransferase 5 as a Therapeutic Target for <i>KRAS</i> Mutated Colorectal Cancer
by: David Shifteh, et al.
Published: (2020-07-01)

Complete and Durable Response to Combined Chemo/Radiation Therapy in <i>EGFR</i> Wild-Type Lung Adenocarcinoma with Diffuse Brain Metastases
by: Davide Adriano Santeufemia, et al.
Published: (2019-04-01)

<i>KRAS</i> and <i>BRAF</i> Mutations as Prognostic and Predictive Biomarkers for Standard Chemotherapy Response in Metastatic Colorectal Cancer: A Single Institutional Study
by: Nuria Garcia-Carbonero, et al.
Published: (2020-01-01)

Activating Mutations in <i>PTPN11</i> and <i>KRAS</i> in Canine Histiocytic Sarcomas
by: Marilia Takada, et al.
Published: (2019-07-01)

Prospective Evaluation of Radiotherapy-Induced Immunologic and Genetic Effects in Colorectal Cancer Oligo-Metastatic Patients with Lung-Limited Disease: The PRELUDE-1 Study
by: Alessandro Ottaiano, et al.
Published: (2021-08-01)

Latest Development in Multiple Myeloma
by: Yoichi Imai
Published: (2020-09-01)

Stereotactic Radiotherapy Followed by Surgical Stabilization Within 24 h for Unstable Spinal Metastases; A Stage I/IIa Study According to the IDEAL Framework
by: Anne L. Versteeg, et al.
Published: (2018-12-01)

The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border
by: Alice Hernandez Grant, et al.
Published: (2021-07-01)

High Frequency of <i>PIK3CA</i> Mutations in Low-Grade Serous Ovarian Carcinomas of Japanese Patients
by: Tomoka Ishibashi, et al.
Published: (2019-12-01)

Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the <i>KRAS</i> Promoter
by: Annalisa Ferino, et al.
Published: (2021-01-01)

Cannot write session to /tmp/vufind_sessions/sess_4rf8spq1lqpdibg1t0pf1rhj70