4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment

4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment

Abstract Background Gastric cancer (GC) has high incidence and mortality worldwide. However, the underlying mechanisms that regulate gastric carcinogenesis are largely undefined. 4.1B is an adaptor protein found at the interface of membrane and the cytoskeleton. Previous studies demonstrated that 4....

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Bibliographic Details
Main Authors: Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An, Pengyuan Zheng
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Cell Communication and Signaling
Subjects:
Gastric cancer
Protein 4.1B
EGFR
Sp1
Tumor suppressor
Online Access:http://link.springer.com/article/10.1186/s12964-019-0431-6

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