Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins

Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathologi...

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Bibliographic Details
Main Authors: Thierry Arnould, Patricia Renard, Anaïs Wanet, Kayleen Vannuvel, Sébastien Michel, Stéphane Demine
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Cells
Subjects:
mitophagy
lipophagy
specific autophagy
organelle dysfunction
triglyceride accumulation
protein secretion
Online Access:http://www.mdpi.com/2073-4409/1/2/168
Description
Summary:Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.
ISSN:2073-4409

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