High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than...

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Main Authors: Sarah S. Al-Otaibi, Faiza Alotaibi, Yaseer Al Zaher, Nabil Al Zaher, M. A. Dababo
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Otolaryngology
Online Access:http://dx.doi.org/10.1155/2017/7296467
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spelling doaj-2546f5155c974fb8b49aa7fcc25c1de62020-11-24T23:19:33ZengHindawi LimitedCase Reports in Otolaryngology2090-67652090-67732017-01-01201710.1155/2017/72964677296467High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual VariantSarah S. Al-Otaibi0Faiza Alotaibi1Yaseer Al Zaher2Nabil Al Zaher3M. A. Dababo4Department of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Otolaryngology, Head & Neck Surgery, King Faisal Specialist Hospital & Research Centre, MBC 47, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Pathology, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaAcinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.http://dx.doi.org/10.1155/2017/7296467
collection DOAJ
language English
format Article
sources DOAJ
author Sarah S. Al-Otaibi
Faiza Alotaibi
Yaseer Al Zaher
Nabil Al Zaher
M. A. Dababo
spellingShingle Sarah S. Al-Otaibi
Faiza Alotaibi
Yaseer Al Zaher
Nabil Al Zaher
M. A. Dababo
High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
Case Reports in Otolaryngology
author_facet Sarah S. Al-Otaibi
Faiza Alotaibi
Yaseer Al Zaher
Nabil Al Zaher
M. A. Dababo
author_sort Sarah S. Al-Otaibi
title High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
title_short High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
title_full High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
title_fullStr High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
title_full_unstemmed High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
title_sort high-grade transformation (dedifferentiation) of acinic cell carcinoma of the parotid gland: report of an unusual variant
publisher Hindawi Limited
series Case Reports in Otolaryngology
issn 2090-6765
2090-6773
publishDate 2017-01-01
description Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.
url http://dx.doi.org/10.1155/2017/7296467
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AT faizaalotaibi highgradetransformationdedifferentiationofaciniccellcarcinomaoftheparotidglandreportofanunusualvariant
AT yaseeralzaher highgradetransformationdedifferentiationofaciniccellcarcinomaoftheparotidglandreportofanunusualvariant
AT nabilalzaher highgradetransformationdedifferentiationofaciniccellcarcinomaoftheparotidglandreportofanunusualvariant
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